New Hope For People Living with HIV: Long-Acting Treatment Breaks Barriers

By Insight Post Uganda


Living with HIV comes with its challenges, and in countries like Uganda, these challenges can be particularly daunting. Daily medication regimens are crucial for suppressing the virus and maintaining health. However, difficulties in adhering to these regimens can hinder progress.

But now, a recent study done in San Francisco-USA brings a ray of hope for people living with HIV in Uganda and similar developing countries. 

Long-acting antiretroviral therapy (LA-ART) injections are emerging as a game-changer in the fight against HIV, offering new possibilities for maintaining viral suppression and improving lives.

The study’s success is a result of collaborative efforts of the National Institutes of Health, the City and County of San Francisco, and the Health Resources and Services Administration, which reflects a united front against a global adversary.

Uganda, like many developing countries, faces a unique set of challenges in managing HIV. Daily adherence to oral antiretroviral therapy (ART) is pivotal for suppressing the virus and maintaining health.

Yet, factors such as unstable living conditions, limited access to medical facilities, and underlying mental health concerns often create insurmountable obstacles to consistent treatment. Against this backdrop, the promise of LA-ART shines brightly.


An observational cohort study aimed to uncover the effectiveness of LA-ART in a real-world context. This single-site study carried immense implications for individuals living with HIV in Uganda. Its focus was to assess LA-ART’s impact on both individuals who already had viral suppression and those experiencing viremia (the presence of a virus in the bloodstream).

The study embraced the diverse spectrum of challenges faced by people living with HIV in Uganda. It enlisted adults representing a range of backgrounds, including those grappling with unstable housing, battling mental illness, and navigating substance use. Despite the complexity of these circumstances, the LA-ART regimen showed its mettle in the face of adversity.

According to the scientist, what sets LA-ART apart is its departure from the conventional daily oral medication regimen. Instead, it introduces periodic injections that sidestep the rigours of daily adherence. This shift offers more than just a change in routine; it provides a lifeline to individuals who struggle with consistent treatment due to multifaceted challenges.

Shaping a Promising Future

The study’s results illuminated a path forward. Among participants with existing viral suppression, LA-ART stood as a stalwart guardian, maintaining their hard-won victories with an impressive 100% success rate. Yet, the most remarkable success story unfolded among those grappling with viremia.

Within a mere 33 days, 95% of these individuals achieved the coveted state of viral suppression—a testament to the power of LA-ART.

Transforming Lives

The significance of LA-ART extends beyond its efficacy statistics. It embodies a transformative potential that extends a lifeline to individuals who have long struggled to keep up with daily treatments. This breakthrough can reshape the landscape of HIV management, not only in Uganda but also in other developing nations grappling with similar challenges.

The scientists noted that collaboration is not bound by geographical constraints; it stands as a beacon of hope for every individual impacted by HIV, regardless of their location.

“As we look ahead, the study’s findings pave the way for a brighter trajectory,” they say, adding that LA-ART holds the potential to rewrite the narrative for people living with HIV, allowing them to reclaim agency over their health.

By eliminating the daily burden of medication adherence and conquering the barriers that have long hindered consistent treatment, LA-ART offers a renewed sense of empowerment.

Disabled PLHV

However, the Disabled Persons Living with HIV/AIDS in the greater Maska region are hopeful that through this breakthrough, the dream of managing HIV with greater ease and efficacy inches closer to reality.

According to Richard Musisi, the Executive Director –Masaka Disabled Persons Living With HIV/AIDS (MADIPHA), as the research continues to unveil its potential, hope is rekindled for millions.

He adds that there is hope for a future where the challenges of HIV are met with unwavering determination, where treatment is not just a regimen, but a beacon of hope lighting the way toward healthier lives.

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